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A 2021 study published in the Journal of Clinical Medicine examining weight loss interventions in fibromyalgia patients found that reductions in BMI were associated with significant improvements in pain scores, fatigue, and quality of life measures, supporting the clinical rationale for weight management as part of fibromyalgia care (Okifuji A and Hare BD, Journal of Clinical Medicine, 2021, GLP-1 Mechanisms Most Relevant to Fibromyalgia Beyond the direct effects of weight loss, there are a few GLP-1-specific mechanisms that may be particularly relevant for fibromyalgia patients